General
Preferred name
SDZ 205557
Synonyms
SDZ-205,557 hydrochloride ()
SDZ 205-557 hydrochloride ()
SDZ-205-557 ()
P&D ID
PD047947
CAS
1197334-02-3
137196-67-9
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dopamine agonist; non-subtype-selective (Tocris Bioactive Compound Library)
DESCRIPTION Potent and selective 5-HT4 serotonin receptor antagonist (LOPAC library)
DESCRIPTION 5-HT4/5-HT3 receptor antagonist (Tocriscreen Total)
DESCRIPTION SDZ 205-557 hydrochloride is a 5-HT3/5-HT4 receptor antagonist that can promote intestinal peristalsis and gastric emptying. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
11
BOC Sciences Bioactive Compounds
sdz-205-557-hydrochloride-cas-1197334-02-3-item-170603
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMP3EXG
Guide to Pharmacology
258
Ki Database
SDZ 205557
LOPAC library
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
2037
Tocriscreen Total
ZINC Tool Compounds
ZINC000001544798
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
300.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
2.43
TPSA
64.79
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT4
Primary Target
5-HT4 Receptors
MOA
Antagonist
5-HT4 and 5-HT3 antagonist
serotonin receptor antagonist
Member status
member
Target
HTR3A, HTR3B
Source data