General
Preferred name
NAN-190
Synonyms
NAN-190 hydrobromide ()
1-(2-METHOXYPHENYL)-4-[4-(2-PHTHALIMIDO)BUTYL]PIPERAZINE ()
NAN-190 (hydrobromide) ()
NAN 190 ()
P&D ID
PD047928
CAS
115338-32-4
102392-05-2
Tags
drug candidate
natural product
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent, standard H3 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
5-HT1A antagonist
(Tocriscreen Total)
DESCRIPTION
The hydrobromide salt form of NAN-190 which is an effective antagonist of 5-HT1A serotonin receptor.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent 5-HT1A serotonin receptor antagonist that lacks TFMPP-like stimulus properties
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
393.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
2
cLogP
2.89
TPSA
53.09
Fraction CSP3
0.39
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
Primary Target
5-HT1A Receptors
MOA
Antagonist
5-HT1A Receptor Antagonists
ADRA2A antagonist
"5-HT1A Receptor Antagonists
ADRA2A antagonist"
serotonin receptor agonist
Member status
member
Target
ADRA1A, ADRA1B, ADRA1D, HTR1A, HTR1F
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Solubility
10 mM in DMSO
Source data
