General
Preferred name
TAPRENEPAG
Synonyms
CP-544326 ()
CP544326 ()
CP 544,326 ()
PF04217329 ()
P&D ID
PD047852
CAS
752187-80-7
Tags
available
drug candidate
Drug indication
Glaucoma/ocular hypertension
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Taprenepag (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors[1].
PRICE 94
DESCRIPTION Taprenepag is a prostanoid EP2 receptor agonist in clinical development for ocular hypertension/glaucoma . Chemically PF-04217329 is the pro-drug taprenepag isopropyl (PubChem CID 23729077), the active acid metabolite of which is CP-544326, as depicted here. (GtoPdb)
DESCRIPTION Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. (TargetMol Bioactive Compound Library)
Compound Sets
13
AdooQ Bioactive Compound Library
A15853
Cayman Chemical Bioactives
22945
ChEMBL Drugs
CHEMBL2107783
Drug Repurposing Hub
DrugBank
DB12623
DrugMAP
DM1TSHL
EU-OPENSCREEN Bioactive Compound Library
EOS101168
EUbOPEN Chemogenomics Library
EUB0000485
Guide to Pharmacology
5816
MedChem Express Bioactive Compound Library
HY-14899
ReFrame library
Selleckchem Bioactive Compound Library
cp544326
TargetMol Bioactive Compound Library
T3174
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
478.13
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
4
cLogP
3.12
TPSA
114.62
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PGE2
Prostaglandin Receptor
PTGER2
MOA
prostaglandin receptor agonist
Pathway
GPCR/G protein
Immunology/Inflammation
Recommended Cell Concentration
100 nM
Source data