General
Preferred name
PD047820
Synonyms
1-(1-Naphthyl)piperazine hydrochloride ()
1-NP ()
1-naphthalen-1-ylpiperazine hydrochloride ()
1-(Naphthalen-1-yl)piperazine hydrochloride ()
1-naphthylpiperazine ()
1-(1-Naphthyl) piperazine hydrochloride ()
1-(1-Naphthyl)piperazine (hydrochloride) ()
P&D ID
PD047820
CAS
57536-86-4
104113-71-5
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION 5-HT2 serotonin receptor antagonist (LOPAC library)
DESCRIPTION 1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION 1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
10
BOC Sciences Bioactive Compounds
4-naphthalen-1-yl-piperazin-1-ium-chloride-cas-104113-71-5-351953
Cayman Chemical Bioactives
16150
DrugMAP
DM6BIWK
EU-OPENSCREEN Bioactive Compound Library
EOS102383
Guide to Pharmacology
3
Ki Database
1-NP
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-4447428643
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T21569
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
212.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
2.25
TPSA
15.27
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT2
Member status
virtual
Source data