General
Preferred name
CYANOPINDOLOL
Synonyms
Cyanopindolol hemifumarate ()
CYANOPINDOLOL(+/-) ()
CYANOPINDOLOL(+) ()
CYANOPINDOLOL(-) ()
P&D ID
PD047799
CAS
69906-86-1
69906-85-0
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The structure of ligand as specified by the PDB compound link corresponds to CID 46937143, and shows structural differences from the structure shown here and represented by CID 155346.
(GtoPdb)
DESCRIPTION
Cyanopindolol is an ¦Â3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively)[1][2][3].
DESCRIPTION
5-HT1A/1B antagonist. Also β-adrenergic antagonist
(Tocriscreen Total)
DESCRIPTION
5-HT2 antagonist. Has moderate affinity for 5-HT6
(Tocris Bioactive Compound Library)
DESCRIPTION
Cyanopindolol hemifumarate is the hemifumarate salt of cyanopindolol, which is a 5-HT1A/1B antagonist. It is also a β-adrenoceptor antagonist. It has roughly equal affinity for each receptor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
DrugMAP
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
287.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
2.17
TPSA
81.07
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
5-HT1A Receptors
MOA
Antagonist
Target
5-HT Receptor
Adrenergic Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data
