General
Preferred name
[<sup>3</sup>H]4-DAMP
Synonyms
4-DAMP methiodide ()
4-DAMP ()
P&D ID
PD047783
CAS
1952-15-4
81405-11-0
106458-69-9
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION M3 muscarinic acetylcholine receptor antagonist. (LOPAC library)
DESCRIPTION Muscarinic M3 antagonist (Tocriscreen Total)
DESCRIPTION 4-DAMP is a potent and selective antagonist of the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors. Blockade of mAChR M2 leads to a decrease of blood pressure in dose manner in spotaneously hypertensive rats. (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective kappa agonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
15
BOC Sciences Bioactive Compounds
4-damp-cas-1952-15-4-item-196631
Cayman Chemical Bioactives
14574
Concise Guide to Pharmacology 2017/18
307
Concise Guide to Pharmacology 2019/20
307
Concise Guide to Pharmacology 2021/22
11497
307
Concise Guide to Pharmacology 2023/24
11497
307
Drug Repurposing Hub
DrugMAP
DMZIUQ2
DrugMatrix
Guide to Pharmacology
11497
307
Ki Database
4-DAMP
LOPAC library
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
0482
Tocriscreen Total
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
324.2
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.6
TPSA
26.3
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
M3
Primary Target
M3 Receptors
MOA
Antagonist
CHRM3 antagonist
cholinergic receptor antagonist
Member status
virtual
Target
CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
Source data