General
Preferred name
SB-258719
Synonyms
CHEMBL12264 ()
SB 258719 hydrochloride ()
SB 258719 ()
P&D ID
PD047781
CAS
1217674-10-6
195199-95-2
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
P&D approved
experimental probe
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SB 258719 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease[1][2][3].
PRICE
61
MOA
Antagonist
(Chemical Probes.org)
DESCRIPTION
SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Dual TP/DP2 (CRTH2) receptor antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist, displaying > 100-fold selectivity over a range of other receptors. SB 258719 shows inverse action on hypothermic effect of 5-CT in mice following i.p. administration.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
BOC Sciences Bioactive Compounds
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
338.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
3.13
TPSA
40.62
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Serotonin 7 (5-HT7) receptor
5-HT7
5-HT Receptor
HTR7
Primary Target
5-HT7 Receptors
MOA
Antagonist
5-HT7 Antagonists
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Target class
GPCR
Target subclass
Serotonin Receptor
Recommended Cell Concentration
1 uM
Source data
