General
Preferred name
VUF 8430
Synonyms
VUF 8430 dihydrobromide ()
VUF 8430 (dihydrobromide) ()
VUF8430 ()
VUF8430 (hydrobromide) ()
P&D ID
PD047769
CAS
100130-32-3
98021-17-1
Tags
drug candidate
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
mGlu1 inverse agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
VUF 8430 dihydrobromide is a high affinity (pKi = 7.5) and potent histamine H4 receptor full agonist (pEC50 = 7.3). VUF 8430 also has moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
161.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.11
TPSA
114.27
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Histamine H4 Receptors
MOA
Agonist
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Recommended Cell Concentration
1 uM
Target
Histamine Receptor
Source data
