General
Preferred name
PRADIGASTAT
Synonyms
LCQ-908 ()
PRADIGASTAT SODIUM ()
Lcq908 - dgat-1-inhibitor ()
LCQ-908-NXA ()
LCQ-908NXA ()
LCQ908-NXA ()
Lcq908a ()
LCQ-908ABA ()
Lcq-908a ()
LCQ-908-ABA ()
LCQ908-ABA ()
Lcq-908 sodium salt ()
P&D ID
PD047656
CAS
956136-98-4
956136-95-1
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
3.0
Drug indication
Non-alcoholic fatty liver disease
type 2 diabetes mellitus
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pradigastat is a potent and selective inhibitor of diacylglycerol O-acyltransferase 1 (DGAT1).
The PubChem CID 53387035 shows the molecule with no stereochemistry. (GtoPdb)
DESCRIPTION Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 ¦ÌM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 ¦ÌM, 1.66¦ÌM, 3.34¦ÌM and 0.973¦ÌM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro[1][2][3][4].
PRICE 230
DESCRIPTION Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes.
Compound Sets
10
Cayman Chemical Bioactives
42025
ChEMBL Drugs
CHEMBL2364624
CHEMBL2364625
Drug Repurposing Hub
DrugBank
DB12866
Guide to Pharmacology
7830
Mcule NIBR MoA Box Subset
MCULE-5242665943
MedChem Express Bioactive Compound Library
HY-16278
Novartis Chemogenetic Library (NIBR MoA Box)
Pandemic Response Box
ReFrame library
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
455.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
6.65
TPSA
75.11
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
Diacylglycerol Acyltransferase type 1 (DGAT-1) Inhibitors
diacylglycerol O acyltransferase inhibitor
Target
DGAT1
Acyltransferase
BCRP
OAT
Pathway
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Source data