General
Preferred name
ENCENICLINE
Synonyms
EVP-6124 ()
ENCENICLINE HYDROCHLORIDE ()
EVP-6124 (hydrochloride) ()
Encenicline, HCl salt ()
Encenicline (EVP-6124) hydrochloride ()
Enceniclina ()
MT4666 ()
MT-4666 ()
EVP-6124 HYDROCHLORIDE ()
P&D ID
PD047620
CAS
550999-75-2
550999-74-1
Tags
available
drug candidate
Drug indication
Liver disease
Schizophrenia
Alzheimer disease
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This compound was developed as part of EnVivo Pharmaceuticals alpha-7 agonist program . The compound exhibits good brain penetration and an adequate exposure time for clinical utility .
EnVivo changed its name to FORUM Pharmaceuticals Inc. in April 2014. (GtoPdb)
DESCRIPTION Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of ¦Á7 neuronal nicotinic acetylcholine receptors (nAChRs).
PRICE 167
DESCRIPTION Encenicline (EVP-6124) is a selective ??7 nicotinic acetylcholine receptor (nAChRs) agonist being developed to treat cognitive impairment in schizophrenia and Alzheimer's disease.
DESCRIPTION EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). It shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs and improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. (BOC Sciences Bioactive Compounds)
DESCRIPTION EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory disorders such as Alzheimer's, to be required to activate the receptor. In this scenario, research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Alzheimer's drugs. (BOC Sciences Bioactive Compounds)
DESCRIPTION Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist being developed to treat cognitive impairment in schizophrenia and Alzheimer's disease. (TargetMol Bioactive Compound Library)
Compound Sets
17
BOC Sciences Bioactive Compounds
evp-6124-cas-550999-75-2-item-84-463285
encenicline-hcl-salt-cas-550999-74-1-item-84-462275
Cayman Chemical Bioactives
30073
ChEMBL Drugs
CHEMBL2151572
CHEMBL3137323
Concise Guide to Pharmacology 2017/18
6926
Concise Guide to Pharmacology 2019/20
6926
Concise Guide to Pharmacology 2021/22
6926
Concise Guide to Pharmacology 2023/24
6926
Drug Repurposing Hub
DrugBank
DB11726
DrugMAP
DMLQO7F
EU-OPENSCREEN Bioactive Compound Library
EOS101539
Guide to Pharmacology
6926
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2151572
MedChem Express Bioactive Compound Library
HY-15430A
ReFrame library
Selleckchem Bioactive Compound Library
encenicline-hydrochloride
TargetMol Bioactive Compound Library
T7193
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
320.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
2
cLogP
3.38
TPSA
32.34
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.92
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
Membrane Transporter/Ion Channel
Neuroscience
Target
nAChR
CHRNA7
AChR
MOA
acetylcholine receptor agonist
Source data