General
Preferred name
ADX71743
Synonyms
(+/-)-ADX 71743 ()
P&D ID
PD047588
CAS
1431641-29-0
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 has anxiolytic-like activity[1][2].
DESCRIPTION ADX71743 is a negative allosteric modulator (NAM) of mGlu7 . (GtoPdb)
DESCRIPTION D1 agonist (Tocris Bioactive Compound Library)
Compound Sets
12
Axon Medchem Screening Library
2732
Concise Guide to Pharmacology 2017/18
6217
Concise Guide to Pharmacology 2019/20
6217
Concise Guide to Pharmacology 2021/22
6217
Concise Guide to Pharmacology 2023/24
6217
Concise Guide to Pharmacology 2025/26
6217
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM3WAG6
EUbOPEN Chemogenomics Library
EUB0002391
Guide to Pharmacology
6217
MedChem Express Bioactive Compound Library
HY-110278
Tocris Bioactive Compound Library
5715
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
269.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
3.77
TPSA
43.1
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Glutamate (Metabotropic) Group III Receptors
MOA
Modulator
Target
mGLuR7 NAM
mGluR
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
1 uM
Source data