General
Preferred name
FLAVANONE
Synonyms
2-Phenyl-4-chromanone ()
4-Flavanone ()
2,3-Dihydroflavone ()
2-Phenylchroman-4-one ()
2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one ()
P&D ID
PD047514
CAS
487-26-3
24271-98-5
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for ERK/p38/NF-¦ÊB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy[1][2].
PRICE 29
DESCRIPTION Flavanones show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. (Enamine Bioactive Compounds)
DESCRIPTION Flavanone (2-Phenylchroman-4-one)s from citrus fruits have also been shown to exert beneficial effects on human vascular function. In particular, chronic interventions with orange juice, or the pure flavanone hesperidin, resulted in a decrease in blood pressure in overweight volunteers and acute improvements in microvascular reactivity. (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
1
Compound Sets
7
DrugMAP
DMNWIYM
Enamine Bioactive Compounds
EBC-04233
Guide to Pharmacology
408
MedChem Express Bioactive Compound Library
HY-N7128
Selleckchem Bioactive Compound Library
flavanone
TargetMol Bioactive Compound Library
T0530
The Spectrum Collection
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
224.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.39
TPSA
26.3
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Aromatase
Cytochrome P450
ERK
MMP
NF-κB
p38 MAPK
PAI-1
antioxidant
Pathway
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Stem Cell/Wnt
Endocrinology/Hormones
NF-¦ÊB
Source data