General
Preferred name
PPADS
Synonyms
PPADS tetrasodium salt ()
PPADS (tetrasodium) ()
PPADS (sodium salt) ()
PPADS tetrasodium ()
P&D ID
PD047473
CAS
192575-19-2
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The structure of this ligand was drawn from the image in . There is some variation in representations of the structure elsewhere, which include CID 6093163.
(GtoPdb)
PRICE
65
DESCRIPTION
PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca2? exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma inhibits P2X1, P2X-2, P2X-3, and P2X- 5. 5.
DESCRIPTION
5-HT3 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective P2 receptor antagonist which blocks responses at both pre- and post-junctional sites
(LOPAC library)
DESCRIPTION
PPADS tetrasodium salt, a non-selective P2 purinergic antagonist, blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. It delays onset of calcium responses to mild hypoosmotic stress in cortical slices.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Other bioactive compounds
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
510.98
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
5
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
1.43
TPSA
250.41
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.15
Structural alerts
1
azo_A(324)
[#7;!R]=[#7]
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Selectivity
P2
Primary Target
Purinergic (P2X) Receptors
MOA
Antagonist
Pathway
Membrane Transporter/Ion Channel
Target
Na+/Ca2+ Exchanger
P2X Receptor
Source data
