General
Preferred name
ENDOMORPHIN-1
Synonyms
Endomorphin 1 ()
Endomorphin 1 (acetate) ()
Endomorphin 1 trifluoroacetate salt ()
Endomorphin 1 acetate ()
Endomorphin 1 (trifluoroacetate salt) ()
P&D ID
PD047469
CAS
189388-22-5
1276123-71-7
Tags
drug candidate
biased GPCR ligand
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The amino acid sequence of endomorphin-1 is believed to be common across mammalian species .
An endogenous peptide, the gene encoding the endomorphin precursor has not yet been identified . (GtoPdb)
An endogenous peptide, the gene encoding the endomorphin precursor has not yet been identified . (GtoPdb)
DESCRIPTION
Endomorphin 1 acetate, a high affinity, highly selective agonist of the ¦Ì-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Endomorphin 1 acetate has antinociceptive properties[1][2][4].
DESCRIPTION
Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Endomorphin 1, an endogenous neuropeptide, is found in the brain and, to a lesser extent, in the spinal cord. It is an agonist of μ-opioid receptor (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties, which is selective for μ- over δ- and κ-opioid receptors (Ki = 1,506 and 5,428 nM, respectively).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Endomorphin 1 acetate is a selective and highly effective μ-opioid receptor agonist with anti-nociceptive and analgesic effects. Endomorphin 1 acetate shows high affinity for kappa3 and can be used to study neurological diseases.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BiasDB
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
DrugMAP
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
610.29
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
6
Rotatable Bonds
12
Ring Count
5
Aromatic Ring Count
4
cLogP
1.67
TPSA
183.64
Fraction CSP3
0.29
Chiral centers
4.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
μ-opioid receptor
Opioid Receptor
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data
