General
Preferred name
ENDOMORPHIN-1
Synonyms
Endomorphin 1 (acetate) ()
Endomorphin 1 ()
Endomorphin 1 trifluoroacetate salt ()
Endomorphin 1 (trifluoroacetate salt) ()
P&D ID
PD047469
CAS
189388-22-5
1276123-71-7
Tags
available
drug candidate
natural product
biased GPCR ligand
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The amino acid sequence of endomorphin-1 is believed to be common across mammalian species .

An endogenous peptide, the gene encoding the endomorphin precursor has not yet been identified . (GtoPdb)
DESCRIPTION Endomorphin 1, an endogenous neuropeptide, is found in the brain and, to a lesser extent, in the spinal cord. It is an agonist of μ-opioid receptor (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties, which is selective for μ- over δ- and κ-opioid receptors (Ki = 1,506 and 5,428 nM, respectively). (BOC Sciences Bioactive Compounds)
Compound Sets
7
BiasDB
Endomorphin-1
BOC Sciences Bioactive Compounds
endomorphin-1-trifluoroacetate-salt-334142
Cayman Chemical Bioactives
23280
DrugMAP
DMBJUEM
Guide to Pharmacology
1623
MedChem Express Bioactive Compound Library
HY-P0185
HY-P0185A
TargetMol Bioactive Compound Library
TQ0267
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
610.29
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
6
Rotatable Bonds
12
Ring Count
5
Aromatic Ring Count
4
cLogP
1.67
TPSA
183.64
Fraction CSP3
0.29
Chiral centers
4.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??-opioid receptor
Opioid Receptor
Source data