General
Preferred name
HTMT
Synonyms
HTMT dimaleate ()
HTMT (maleate) ()
P&D ID
PD047460
CAS
195867-54-0
103827-16-3
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
HTMT (dimaleate) is a histamime H1 and H2 receptor agonist.
DESCRIPTION
HTMT (dimaleate) is a histamime H1 and H2 receptor agonist .
(GtoPdb)
DESCRIPTION
beta1 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
H1 / H2 agonist
(Tocriscreen Total)
DESCRIPTION
HTMT dimaleate is a histamine H1 and H2 receptor agonist with 4x104 fold activity over histamine in H2-mediated effects in natural suppressor cells. HTMT dimaleate increases intracellular Ca2+ and IP3 in lymphocytes through a binding site except for H1, H2 or H3.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
Guide to Pharmacology
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
382.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
2
cLogP
4.15
TPSA
69.81
Fraction CSP3
0.47
Chiral centers
1.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Histamine H1 Receptors
MOA
Agonist
HRH1 agonist
Member status
virtual
Source data
