General
Preferred name
IMETIT
Synonyms
Imetit dihydrobromide ()
Imetit (dihydrobromide) ()
VUF 8325 (dihydrobromide) ()
SKF 91105 (dihydrobromide) ()
Imetit (hydrobromide) ()
P&D ID
PD047457
CAS
32385-58-3
102203-18-9
Tags
drug candidate
biased GPCR ligand
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Imetit (dihydrobromide) is a standard H3 and H4 receptor agonist (affinity H3 > H4). (GtoPdb)
DESCRIPTION High affinity melatonin agonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent and selective H3 histamine receptor agonist (LOPAC library)
DESCRIPTION Standard H3 and H4 agonist (H3 > H4) (Tocriscreen Total)
DESCRIPTION Imetit dihydrobromide is a potent and high affinity agonist at histamine H3 and H4 receptors (Ki = 0.3 and 2.7 nM, respectively). It induces an eosinophil shape change (EC50 = 25 nM). (BOC Sciences Bioactive Compounds)
Compound Sets
16
Axon Medchem Screening Library
1325
BiasDB
Imetit
BOC Sciences Bioactive Compounds
imetit-dihydrobromide-cas-32385-58-3-item-16882
Cayman Chemical Bioactives
29517
Drug Repurposing Hub
DrugMAP
DMMJ6NS
DrugMatrix
Guide to Pharmacology
1250
Ki Database
Imetit
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-4066513770
MedChem Express Bioactive Compound Library
HY-101173
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
0729
Tocriscreen Total
ZINC Tool Compounds
ZINC000005425255
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
170.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.58
TPSA
78.55
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
5.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H3
Primary Target
Histamine H3 Receptors
MOA
Agonist
HRH3 agonist
Histamine Receptor agonist
Member status
virtual
Target
HRH3, HRH4
H3 agonist
Histamine Receptor
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data