General
Preferred name
UPROSERTIB
Synonyms
Uprosertib hydrochloride ()
GSK2141795 (hydrochloride) ()
GSK2141795, GSK2141795C ()
GSK2141795 ()
GSK795 ()
GSK2141795 hydrochloride ()
Uprosertib (GSK2141795) ()
AKT INHIBITOR GSK-2141795 ()
AKT INHIBITOR GSK2141795 ()
GSK-2141795 ()
GSK-2141795C ()
GSK2141795C ()
P&D ID
PD047342
CAS
1047634-65-0
1047635-80-2
Tags
available
drug candidate
Drug indication
Colorectal cancer
Lymphoma
Neoplasm
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Uprosertib (GSK-2141795) is an inhibitor of the AKT family of protein kinases . (GtoPdb)
DESCRIPTION Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.
DESCRIPTION Uprosertib is a potent and selective inhibitor of RAC-beta serine/threonine-protein kinase (IC50 = 1nM), RAC-gamma serine/threonine-protein kinase (IC50= 1.3nM), RAC-alpha serine/threonine-protein kinase (IC50= 4.7-8.3nM). (Enamine Bioactive Compounds)
DESCRIPTION GSK2141795 Hcl is a potent and selective pan-Akt inhibitor with IC50s of 180/328/38 nM for Akt1/Akt2/Akt3 respectively. (BOC Sciences Bioactive Compounds)
Cell lines
10
Organisms
0
Compound Sets
15
BOC Sciences Bioactive Compounds
gsk2141795-hydrochloride-cas-1047635-80-2-item-84-463504
Cayman Chemical Bioactives
19904
ChEMBL Drugs
CHEMBL3137336
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB11969
DrugMAP
DMSHE70
Enamine Bioactive Compounds
EBC-157250
EU-OPENSCREEN Bioactive Compound Library
EOS101515
Guide to Pharmacology
7902
MedChem Express Bioactive Compound Library
HY-15965
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
gsk2141795
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
428.06
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.56
TPSA
86.08
Fraction CSP3
0.22
Chiral centers
1.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Akt
AKT1, AKT2, AKT3
AKT2
AKT3
Pathway
PI3K/Akt/mTOR
Targets
AKT1
MOA
Akt inhibitor
Source data