General
Preferred name
SB 216641
Synonyms
SB 216641 hydrochloride ()
SB-216641 ()
SB-216641 (hydrochloride) ()
P&D ID
PD047255
CAS
193611-67-5
170230-39-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
High affinity D3 agonist (D3 greater than or equal to D2 > D4)
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective h5-HT1B antagonist
(Tocriscreen Total)
DESCRIPTION
SB 216641 hydrochloride is a selective h5-HT1B antagonist with ~ 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
486.23
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
4
cLogP
5.22
TPSA
89.72
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
5-HT1B Receptors
MOA
Antagonist
serotonin receptor antagonist
Target
HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C
5-HT1B antagonist
Source data
