General
Preferred name
TM-38837
Synonyms
TM38837 ()
TM 38837 ()
CB1 antagonist 4 ()
P&D ID
PD047173
CAS
1253641-65-4
Tags
available
drug candidate
Drug indication
Obesity
Metabolic disorder
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TM-38837 is a cannabinoid CB1 receptor selective inverse agonist/antagonist . This compound has been designed to be peripherally restricted so as to avoid the severe CNS side effects (depression, anxiety and stress disorders) which lead to the withdrawl of , the first CB1 receptor antagonist to receive marketing approval. TM-38837 has been investigated as a treatment for obesity and metabolic disorders. (GtoPdb)
DESCRIPTION Selective mu receptor agonist (Tocris Bioactive Compound Library)
DESCRIPTION TM-38837 is a peripheral selective cannabinoid receptor 1 (CB1) receptor antagonist. (BOC Sciences Bioactive Compounds)
Compound Sets
6
BOC Sciences Bioactive Compounds
tm-38837-cas-1253641-65-4-316873
DrugMAP
DMCFGD4
Guide to Pharmacology
8705
MedChem Express Bioactive Compound Library
HY-112340
TargetMol Bioactive Compound Library
T8511
Tocris Bioactive Compound Library
7131
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
616.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
4
cLogP
8.02
TPSA
50.16
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuronal Signaling
Target
CB1
Cannabinoid Receptor
Primary Target
CB1 Receptors
MOA
Inverse Agonist
Solubility
Soluble in DMSO, Ethanol
Source data