General
Preferred name
CCG 203769
Synonyms
4-butyl-2-ethyl-1,2,4-thiadiazolidine-3,5-dione ()
RGS4 inhibitor 11b ()
thiadiazolidinone (TDZD) deriv. 6 ()
P&D ID
PD047149
CAS
410074-60-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CCG 203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-G¦Áo protein-protein interaction in vitro with an IC50 of 17 nM.
PRICE 169
DESCRIPTION CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-G??o protein-protein interaction.
DESCRIPTION This compound is a potent small molecule inhibitor of regulator of G-protein signaling protein 4 (RGS4) . (GtoPdb)
DESCRIPTION CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction. (TargetMol Bioactive Compound Library)
Compound Sets
9
Concise Guide to Pharmacology 2017/18
8033
Concise Guide to Pharmacology 2019/20
8033
Concise Guide to Pharmacology 2021/22
8033
Concise Guide to Pharmacology 2023/24
8033
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM9CF45
Guide to Pharmacology
8033
MedChem Express Bioactive Compound Library
HY-U00431
TargetMol Bioactive Compound Library
T10705
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
202.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
0.89
TPSA
44.0
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
5.0
QED
0.73
QED
0.73
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
RGS4
RGS19
RGS16
RGS8
GSK-3β
D2 receptor
RGS Protein
Pathway
GPCR/G protein
Neuroscience
PI3K/Akt/mTOR signaling
Stem Cells
Source data