General
Preferred name
PRE-084
Synonyms
PRE-084 hydrochloride ()
Pre 084 ()
PRE-084 (hydrochloride) ()
PRE-084 HCl ()
P&D ID
PD047121
CAS
138847-85-5
75136-54-8
Tags
available
drug candidate
Drug indication
Aging skin
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PRE-084 hydrochloride is a highly selective ¦Ò1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].
PRICE
46
DESCRIPTION
PRE-084 hydrochloride is a selective agonist of ??1(IC50:44 nM, in the sigma receptor assay).
DESCRIPTION
Specific sigma ligand, NMDA antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and highly selective sigma1 receptor agonist
(LOPAC library)
DESCRIPTION
Highly selective σ1 agonist
(Tocriscreen Total)
DESCRIPTION
Highly selective sigma1 agonist
(Tocriscreen Plus)
DESCRIPTION
PRE-084 hydrochloride is a high affinity, selective receptors exhibiting neuroprotective effects. Its IC50 value is 44 nM in the sigma receptor assay. In vitro, it has an IC50 of more than 100,000 nM for PCP receptors. In vivo, it has nootropic and antidepressant actions and has antitussive and reinforcing effects. It could improve motor neuron survival and motor performance in wobbler mice. It enhances BDNF-mediated trophic support.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
19
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
317.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
2.76
TPSA
38.77
Fraction CSP3
0.63
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Other Pharmacology
Selectivity
sigma1
Target
Sigma Receptor
σ1
¦Ò1
SIGMAR1
Sigma-1 agonist
Akt
NO Synthase
Primary Target
?1 Receptors
MOA
Agonist
Sigma Receptor agonist
Pathway
Immunology/Inflammation
Neuronal Signaling
PI3K/Akt/mTOR
GPCR/G protein
Solubility
DMSO:34mg/mL
Source data
