General
Preferred name
N-METHYLHISTAMINE
Synonyms
N α-Methylhistamine dihydrochloride ()
Nα-Methylhistamine FA(673-50-7 Free base) ()
N-alpha-methylhistamine ()
N-alpha-Methylhistamine-dihydrochloride ()
N-[3H]alpha-methylhistamine ()
N'-Methylhistamine ()
N-Methylhistamine (dihydrochloride) ()
Nα-Methylhistamine (dihydrochloride) ()
Nα-Methylhistamine dihydrochloride ()
N-METHYLHISTAMINE DIHYDROCHLORIDE ()
Nα-Methylhistamine FA ()
N-[3H]α-methylhistamine ()
[2-(1H-Imidazol-4-yl)ethyl](methyl)amine dihydrochloride ()
N??-Methylhistamine FA ()
P&D ID
PD047104
CAS
673-50-7
68236-25-9
16503-22-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 369
DESCRIPTION N??-Methylhistamine FA is a histamine H3 receptor agonist
DESCRIPTION Non-selective H3 agonist (Tocriscreen Total)
DESCRIPTION Nα-Methylhistamine dihydrochloride, a production of Nα-Methylhistamine (NAMH), is a potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Nα-Methylhistamine is a potent H2R agonist as well as a H3R agonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION [2-(1H-Imidazol-4-yl)ethyl](methyl)amine is an agonist of histamine H3-receptor. (Enamine Bioactive Compounds)
DESCRIPTION Nα-Methylhistamine FA is a histamine H3 receptor agonist (TargetMol Bioactive Compound Library)
Compound Sets
17
BOC Sciences Bioactive Compounds
n-methylhistamine-dihydrochloride-cas-16503-22-3-item-153158
Concise Guide to Pharmacology 2017/18
1240
Concise Guide to Pharmacology 2019/20
1240
Concise Guide to Pharmacology 2021/22
1240
Concise Guide to Pharmacology 2023/24
1240
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMCFH5W
DMWDCV1
Enamine Bioactive Compounds
EBC-280042
EU-OPENSCREEN Bioactive Compound Library
EOS101976
Guide to Pharmacology
1239
1240
JUMP-Target 1 Compound Set
912
Ki Database
N-alpha-methylhistamine
N-methylhistamine
MedChem Express Bioactive Compound Library
HY-101005
ReFrame library
TargetMol Bioactive Compound Library
T23038L
Tocriscreen Total
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
125.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.17
TPSA
40.71
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
5.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
HRH4
Histamine Receptor
H3 receptor
MOA
Histamine Receptor agonist
Source data