General
Preferred name
PZM21
Synonyms
PZM-21 ()
P&D ID
PD046947
CAS
1997387-43-5
Tags
available
drug candidate
biased GPCR ligand
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PZM21 is a potent, selective μ opioid receptor agonist with bias towards G-protein (Gi) activation over β-arrestin 2 recruitment . This provides a compound with reduced propensity to produce common opioid side effects whilst retaining analgesic activity. PZM21 is being used experimentally for its analgesic activity.
This compound is not in PubChem and its SMILES string does not retrieve any patent documents from SureChembl (late August 2016).
Compare this with , a chemically unrelated μ opioid receptor G-protein biased agonist. (GtoPdb)
DESCRIPTION Potent and high affinity H2 biased inverse agonist (Tocris Bioactive Compound Library)
Compound Sets
10
AdooQ Bioactive Compound Library
A20586
BiasDB
PZM21
Cayman Chemical Bioactives
20576
DrugBank
DB14030
Enamine BioReference Compounds
Guide to Pharmacology
9286
MedChem Express Bioactive Compound Library
HY-101386
ReFrame library
TargetMol Bioactive Compound Library
T4386
Tocris Bioactive Compound Library
7218
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
361.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
2.86
TPSA
64.6
Fraction CSP3
0.42
Chiral centers
2.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Endocrinology/Hormones
GPCR/G protein
Neuronal Signaling
Target
?? opioid receptor
¦Ì-opioid receptor
Opioid Receptor
Primary Target
Mu Opioid Receptors
MOA
Opioid Receptor agonist
Agonist
Source data