General
Preferred name
BASIMGLURANT
Synonyms
CTEP Derivative ()
RG7090 ()
RG-7090 ()
Basimglurant sulfate ()
NOE-101 ()
RO4917523 ()
RO4917523-009 SULPHATE ()
RO-4917523 ()
RO4917523-000 ()
P&D ID
PD046943
CAS
1034442-21-1
802906-73-6
Tags
available
drug candidate
Drug indication
Major depressive disorder
Fragile X syndrome
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM[1]. Basimglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE 198
DESCRIPTION Basimglurant (RO4917523) is a negative allosteric modulator (NAM) of the glutamate metabotropic receptor 5 (mGlu5) GPCR , and is a clinical candidate in development for the treatment of psychiatric diseases. Structurally, basimglurant and are analogues. CTEP has a notably longer half-life in rodents (49 hours) than basimglurant (~10 hours), so is better suited for rodent studies requiring chronic exposure/treatment. (GtoPdb)
DESCRIPTION RG7090 is a negative modulator of metabotropic glutamate receptor subtype 5 (mGluR5; GRM5). (BOC Sciences Bioactive Compounds)
DESCRIPTION Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). (TargetMol Bioactive Compound Library)
Compound Sets
13
BOC Sciences Bioactive Compounds
rg7090-cas-802906-73-6-item-84-463332
Cayman Chemical Bioactives
36806
ChEMBL Drugs
CHEMBL3301626
Drug Repurposing Hub
DrugBank
DB11833
DrugMAP
DMX8JYN
Guide to Pharmacology
9309
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL3301626
Mcule NIBR MoA Box Subset
MCULE-4074341289
MedChem Express Bioactive Compound Library
HY-15446
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T12717
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
325.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
4.08
TPSA
30.71
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
mGluR
mGluR5
GRM5
Member status
virtual
MOA
MGLUR5 NAM
glutamate receptor antagonist
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data