General
Preferred name
AZD-5069
Synonyms
AZD5069 ()
AZD 5069 ()
P&D ID
PD046923
CAS
878385-84-3
Tags
available
drug candidate
Drug indication
Asthma
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.
PRICE 121
DESCRIPTION AZD5069 is a novel, selective antagonist of the chemokine receptor, CXCR2. The structure shown here was drawn from that in , which specifies stereochemistry. This structure is identical to Example 47 in patent US7838675 . PubChem records the structure with no specified stereochemistry (CID 59558839).
Small-molecule antagonists of CXCR2 are being developed for their potential to treat inflammatory conditions. (GtoPdb)
DESCRIPTION AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM). (TargetMol Bioactive Compound Library)
Compound Sets
11
AdooQ Bioactive Compound Library
A15941
Cayman Chemical Bioactives
28297
Drug Repurposing Hub
DrugBank
DB16822
DrugMAP
DM3JSFK
EU-OPENSCREEN Bioactive Compound Library
EOS101481
Guide to Pharmacology
8948
MedChem Express Bioactive Compound Library
HY-19855
ReFrame library
Selleckchem Bioactive Compound Library
azd-5069
TargetMol Bioactive Compound Library
T7681
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
476.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
2
cLogP
1.53
TPSA
124.88
Fraction CSP3
0.44
Chiral centers
2.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CXCR
CXCR2
MOA
CC chemokine receptor antagonist
Pathway
Autophagy
GPCR/G protein
Immunology/Inflammation
Source data