General
Preferred name
HX 531
Synonyms
HX531 ()
P&D ID
PD046877
CAS
188844-34-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION HX531 is an orally active RXR antagonist with an IC50 of 18 nM. HX531 upregulates the p53-p21Cip1 pathway. HX531 abrogates the anti-apoptotic effect of t-RA. HX531 exerts anti-obesity, anti-diabetic and anti-melanoma activities[1][2][3].
PRICE 118
DESCRIPTION HX 531 is an antagonist of retinoid X receptors . Antagonism is generally assessed as the ability of HX 531 to inhibit agonist-induced transactivation of the retinoid X receptors. (GtoPdb)
DESCRIPTION HX 531 is a potent RXR antagonist (IC50 = 18 nM) that inhibits 9-cis retinoic acid-induced transactivation of RXR. HX 531 promotes the differentiation of white and brown pre-adipocyte to white adipocytes, and reduces triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice given a high fat diet. (BOC Sciences Bioactive Compounds)
DESCRIPTION HX 531 is a RXR antagonist (IC50 of 18 nM). HX 531 prevents HF diet-induced obesity, insulin resistance, and diabetes by reducing tissue TG content in white adipose tissue (WAT), skeletal muscle, and liver in mice. (TargetMol Bioactive Compound Library)
DESCRIPTION RXR synergist (Tocris Bioactive Compound Library)
Compound Sets
10
BOC Sciences Bioactive Compounds
hx-531-cas-188844-34-0-item-129502
Cayman Chemical Bioactives
20762
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
8079
Mcule NIBR MoA Box Subset
MCULE-1598581334
MedChem Express Bioactive Compound Library
HY-108521
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T22843
Tocris Bioactive Compound Library
3912
ZINC Tool Compounds
ZINC000027072848
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
483.22
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
3
cLogP
6.89
TPSA
96.04
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
7.0
QED
0.32
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
RXR
MDM-2/p53
RAR/RXR
Primary Target
Retinoid X Receptors
MOA
Antagonist
Retinoid RXR Antagonists
Member status
member
Pathway
Apoptosis
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Metabolism
Source data