General
Preferred name
CV-6209
Synonyms
CV 6209 ()
CV-6209 chloride ()
CV-6209 (chloride) ()
CV-6209-d5 ()
P&D ID
PD046844
CAS
117064-08-1
100488-87-7
Tags
available
drug candidate
Drug indication
Asthma
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CV-6209 is a potent platelet-activating factor (PAF) receptor antagonist, which inhibits aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little effect on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
12
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
606.45
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
25
Ring Count
1
Aromatic Ring Count
1
cLogP
7.48
TPSA
98.05
Fraction CSP3
0.76
Chiral centers
1.0
Largest ring
6.0
QED
0.09
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Target
Platelet-activating Factor Receptor (PAFR)
Source data
