General
Preferred name
desmopressin
Synonyms
dDAVP ()
DESMOPRESSIN ACETATE ()
Desmopressin acetate (16679-58-6 free base) ()
P&D ID
PD046835
CAS
6917-99-3
62357-86-2
16679-58-6
62288-83-9
Tags
available
drug
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Synthetic analogue of AVP. As is the case with many peptide molecules, there is ambiguity in the stereochemistry of the chemical structure of desmopressin. The structure shown here does not specify stereochemistry and so may vary from the representations shown on other resources linked to from the table above. PubChem also includes the following structures for desmopressin: (CID 16051933 and CID 5311065).
(GtoPdb)
DESCRIPTION
Desmopressin acetate (16679-58-6 free base) (DDAVP) is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin acetate (16679-58-6 free base) works by limiting the amount of water that is eliminated in the urine. Desmopressin acetate (16679-58-6 free base) binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates the release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
1068.43
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
13
Rotatable Bonds
19
Ring Count
4
Aromatic Ring Count
2
cLogP
-4.34
TPSA
437.91
Fraction CSP3
0.48
Chiral centers
7.0
Largest ring
20.0
QED
0.03
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Vasopressin receptor 1
vasopressin receptor 1a
Vasopressin receptor 2
Vasopressin Receptor
Pathway
GPCR/G protein
Source data
