General
Preferred name
HC-056456
Synonyms
HC 056456 ()
3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide ()
P&D ID
PD046763
CAS
7733-96-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 ¦ÌM).
PRICE 71
DESCRIPTION HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) is a CatSper channel modulator. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
9
Concise Guide to Pharmacology 2017/18
4212
Concise Guide to Pharmacology 2019/20
4212
Concise Guide to Pharmacology 2021/22
4212
Concise Guide to Pharmacology 2023/24
4212
DrugMAP
DMOG1Q4
EU-OPENSCREEN Bioactive Compound Library
EOS101119
Guide to Pharmacology
4212
MedChem Express Bioactive Compound Library
HY-112729
TargetMol Bioactive Compound Library
T4604
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
305.98
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
1.89
TPSA
87.11
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
5.0
QED
0.54
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CatSper channel
Calcium Channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data