DESCRIPTION BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents[1].

PRICE 321

DESCRIPTION BAY-524 is a Bub1 kinase inhibitor and can be used as a tool compound for investigating Bub1 kinase function.
Using a high-throughput screening approach, the compound (renamed as enterololin) has been identified as a narrow-spectrum Gram-negative antibacterial with specific activity against Enterobacteriaceae spp., while selectively sparing Gram-negative and Gram-positive commensal strains . Generative AI was used to predict the bacterial MOA, with subsequent experimental validation confirming that BAY-524 targets LolCDE , a complex that is essential for the transport of lipoproteins from the inner membrane to the outer membrane of Gram-negative bacteria. (GtoPdb)

DESCRIPTION BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP). (TargetMol Bioactive Compound Library)