General
Preferred name
ABT-639
Synonyms
ABT-639 hydrochloride ()
ABT 639 ()
Abt-639 free base ()
P&D ID
PD046641
CAS
1235560-28-7
Tags
available
drug candidate
Drug indication
Pain
Neuropathic pain
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
PRICE
163
DESCRIPTION
Selective TRPV3 antagonist; brain penetrant
(Tocris Bioactive Compound Library)
DESCRIPTION
ABT-639 is a potent and selective T-type calcium channel blocker.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
455.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
3.34
TPSA
69.72
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
CACNA1G, CACNA1H, CACNA1I
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Primary Target
CaV3.x Channels (T-type)
MOA
Blocker
T-type calcium channel inhibitor
calcium channel blocker
Member status
member
Source data
