General
Preferred name
Ro 04-6790
Synonyms
Ro 04-6790 dihydrochloride ()
RO 04-6790 hydrochloride ()
Ro-04-6790 ()
Ro 04-6790 (hydrochloride hydrate) ()
P&D ID
PD046583
CAS
202466-68-0
1197333-95-1
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective 5-HT6 serotonin receptor antagonist.
(LOPAC library)
DESCRIPTION
RO 04-6790 hydrochloride is a potent and selective serotonin 5-HT6 receptor antagonist.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective, non-competitive mGlu2 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Ro 04-6790 is a potent and selective 5-HT6 receptor antagonist (pKi= 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Some studies indicate that Ro 04-6790 attenuates behavioural effects related to the hypofunction of the NMDA receptor suggesting that this compound might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
Guide to Pharmacology
Ki Database
LOPAC library
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
308.11
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
0.94
TPSA
122.03
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT6
Primary Target
5-HT6 Receptors
MOA
Antagonist
HTR6 antagonist
Member status
virtual
Target
5-HT6 antagonist
Source data
