General
Preferred name
LY-334370
Synonyms
4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide ()
LY 334370 ()
LY 334370 hydrochloride ()
LY334370 ()
[3H]LY334370 ()
LY334370 (hydrochloride) ()
P&D ID
PD046573
CAS
199673-74-0
182563-08-2
Tags
available
drug candidate
Drug indication
Migraine
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.
PRICE
46
DESCRIPTION
Potent and selective CRF1 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
LY 334370 hydrochloride is a 5-HT1F receptor agonist. It shows antimigraine effects.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
351.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
4.37
TPSA
48.13
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
5-HT1F
5-HT1F antagonist
Primary Target
5-HT1F Receptors
MOA
Agonist
serotonin receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data
