General
Preferred name
MK-212
Synonyms
MK 212 hydrochloride ()
MK 212 ()
MK-212 (monohydrochloride) ()
CPP (monohydrochloride) ()
MK212 ()
MK212 hydrochloride ()
MK-212 (hydrochloride) ()
P&D ID
PD046546
CAS
61655-58-1
64022-27-1
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GPR35 agonist (Tocris Bioactive Compound Library)
DESCRIPTION MK212 is a 5HT2C-receptor agonist. It exhibited anxiolytic activity in mice at low doses. It is a serotonin agonist. It could promote the secretion of serum prolactin and cortisol in humans. (BOC Sciences Bioactive Compounds)
DESCRIPTION MK212 hydrochloride is a selective 5-HT2C serotonin receptor agonist. It displays selectivity for 5-HT2C over 5-HT2A with IC50 values of 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively. (BOC Sciences Bioactive Compounds)
Compound Sets
13
Axon Medchem Screening Library
1214
BOC Sciences Bioactive Compounds
mk212-hydrochloride-cas-61655-58-1-476045
mk212-cas-64022-27-1-354341
Cayman Chemical Bioactives
36089
DrugBank
DB12111
DrugMAP
DMYO8T6
DrugMatrix
Guide to Pharmacology
165
Ki Database
MK 212
Mcule NIBR MoA Box Subset
MCULE-1504513589
MedChem Express Bioactive Compound Library
HY-101324A
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T22987
Tocris Bioactive Compound Library
0941
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
198.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
0.54
TPSA
41.05
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT2C
5-HT2C agonist
5-HT Receptor
Primary Target
5-HT2C Receptors
MOA
Agonist
5-HT2C Agonists
Member status
member
Solubility
Soluble in DMSO, not in water
DMSO: ≥20 mg/mL
Source data