General
Preferred name
cilobradine
Synonyms
DK-AH 269 ()
Cilobradine (hydrochloride) ()
Cilobradine hydrochloride ()
Cilobradina ()
P&D ID
PD046484
CAS
147541-45-5
186097-54-1
Tags
available
drug candidate
Drug indication
Cardiac arrhythmias
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
There is some ambiguity in the literature and in other databases as to the exact stereochemistry of Cilobradine. This compound is also represented in the alternative isomer by CID 132989 and CHEMBL2105984.
(GtoPdb)
DESCRIPTION
Cilobradine hydrochloride is a HCN channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects[1][2][3][4][5].
PRICE
217
DESCRIPTION
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
ChEMBL Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
482.28
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
2
cLogP
3.6
TPSA
60.47
Fraction CSP3
0.54
Chiral centers
1.0
Largest ring
7.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HCN Channel
Pathway
Membrane Transporter/Ion Channel
Source data
