General
Preferred name
ALMOREXANT
Synonyms
ACT 078573 ()
ACT 078573 hydrochloride ()
A 573 hydrochloride ()
Orexin-RA-1 hydrochloride ()
ACT-078573 hydrochloride ()
Almorexant HCl ()
Almorexant (hydrochloride) ()
ACT-078573 HCl ()
Almorexant hydrochloride ()
ACT-078573 ()
[3H]-almorexant ()
Almorexant-13C-d3 ()
P&D ID
PD046478
CAS
1266467-63-3
913358-93-7
871224-64-5
2738376-75-3
Tags
available
drug candidate
Drug indication
Sleep-wake disorder
Insomnia
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4].
PRICE 158
DESCRIPTION Almorexant (ACT-078573) is an investigational, oral, dual orexin receptor antagonist (DORA) . Development of ACT-078573 was ceased in 2011, apparently because of the compound's side-effect profile. (GtoPdb)
DESCRIPTION Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4].
PRICE 149
DESCRIPTION A tritiated version of the orexin antagonist ; weakly OX2-selective. Position of tritium ions taken from . (GtoPdb)
DESCRIPTION Almorexant hydrochloride (ACT 078573 hydrochloride) is an orally active dual orexin receptor antagonist that blocks the intracellular Ca2+ signaling pathway and, to a certain extent, blocks the excitatory effects of methamphetamine. Almorexant hydrochloride Induces apoptosis and can be used to study sleep disorders. (TargetMol Bioactive Compound Library)
DESCRIPTION Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
17
AdooQ Bioactive Compound Library
A14286
Cayman Chemical Bioactives
13638
29099
ChEMBL Drugs
CHEMBL455136
Concise Guide to Pharmacology 2017/18
2886
9465
Concise Guide to Pharmacology 2019/20
2886
9465
Concise Guide to Pharmacology 2021/22
2886
9465
Concise Guide to Pharmacology 2023/24
2886
9465
Drug Repurposing Hub
DrugBank
DB06673
DrugMAP
DMQALR5
EU-OPENSCREEN Bioactive Compound Library
EOS101200
Guide to Pharmacology
2886
9465
MedChem Express Bioactive Compound Library
HY-10805A
HY-10805
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
almorexant-hcl
TargetMol Bioactive Compound Library
T6155
T2613
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
512.23
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
5.74
TPSA
50.8
Fraction CSP3
0.34
Chiral centers
2.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
OX Receptor
OX1
OX2
HCRTR1, HCRTR2
Calcium Channel
Caspase
Orexin Receptor (OX Receptor)
Member status
member
MOA
Orexin OX-1 Antagonists
Orexin OX-2 Antagonists
orexin receptor antagonist
Pathway
Apoptosis
GPCR/G protein
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data