General
Preferred name
cyclic GMP
Synonyms
Monosodium-GMP ()
cGMP sodium salt ()
Cyclic guanosine monophosphate ()
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD ()
Cyclic GMP (sodium salt) ()
P&D ID
PD046339
CAS
7665-99-8
40732-48-7
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 33
DESCRIPTION GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin. GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis. (TargetMol Bioactive Compound Library)
Compound Sets
11
Cayman Chemical Bioactives
18821
Concise Guide to Pharmacology 2017/18
2347
Concise Guide to Pharmacology 2019/20
2347
Concise Guide to Pharmacology 2021/22
2347
Concise Guide to Pharmacology 2023/24
2347
DrugBank
DB02315
DrugMAP
DMOU93V
EU-OPENSCREEN Bioactive Compound Library
EOS102336
Guide to Pharmacology
2347
TargetMol Bioactive Compound Library
T5065
ZINC Tool Compounds
ZINC000004095501
External IDs
69
Properties
(calculated by RDKit )
Molecular Weight
345.05
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
-1.52
TPSA
174.81
Fraction CSP3
0.5
Chiral centers
5.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PKG
MOA
PKA
Pathway
Tyrosine Kinase/Adaptors
Source data