General
Preferred name
WAY-100635
Synonyms
WAY-100635 Maleate ()
N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide trihydrochloride ()
Cyclohexanecarboxylic acid {2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-pyridin-2-yl-amide ()
WAY 100,635 ()
WAY 100635 maleate ()
WAY-100635 maleate salt ()
WAY 100635 hydrochloride ()
WAY-100635 (maleate) ()
[11C]WAY100635 ()
[3H]WAY100635 ()
[11C]WAY100635 ()
WAY-100,635 ()
WAY-100635 (maleate) ()
P&D ID
PD046313
CAS
1092679-51-0
146714-97-8
162760-96-5
634908-75-1
162760-97-6
Tags
drug candidate
natural product
available
Drug indication
Eating disorder
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
WAY-100635 is a piperazine drug widely used in scientific studies. As described in our bioactivity tab It was reported as a selective 5-HT1A receptor antagonist in 1998 but subsequent research showed that it also acts as potent full agonist at D4.
(GtoPdb)
DESCRIPTION
Negative allosteric modulator of mGlu5 receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
Highly selective 5-HT1A serotonin receptor antagonist
(LOPAC library)
DESCRIPTION
WAY 100635 hydrochloride is a 5-HT1A receptor antagonist with dopamine D4 agonist activity (Ki values 2.2 nM, 6260 nM, 24 nM, >10,000 nM, 20 nM, 322 nM, and 16 nM for 5-HT1A, 5-HT2A, 5-HT2B, 5-HT7, α1A, α1B, and D4, respectively).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
21
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Ki Database
LOPAC library
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
74
Molecular Weight
422.27
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
2
cLogP
3.83
TPSA
48.91
Fraction CSP3
0.52
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT
HTR1A
5-HT1A antagonist
5-HT Receptor
Dopamine Receptor
Primary Target
5-HT1A Receptors
MOA
Antagonist
serotonin receptor antagonist
Source data
