General
Preferred name
PF-00489791
Synonyms
PF-4634817 ()
PF 4634817 ()
PF00489791 ()
PF 00489791 ()
PF4634817 ()
PF-489791 ()
UK-489,791 ()
PF-489,791 ()
P&D ID
PD046269
CAS
853003-48-2
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Diabetic nephropathy
Raynaud disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC50 of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function[1].
PRICE 335
DESCRIPTION PF-00489791 is a long-acting, selective and competitive inhibitor of phosphodiesterase 5 (gene symbol PDE5A) inhibitor which is reported to reduce systemic blood pressure in patients with hypertension . (GtoPdb)
DESCRIPTION PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy. (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
40464
ChEMBL Drugs
CHEMBL4210847
DrugBank
DB11736
DrugMAP
DM3C8GQ
Guide to Pharmacology
8377
MedChem Express Bioactive Compound Library
HY-14464
ReFrame library
TargetMol Bioactive Compound Library
T28360
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
476.2
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
3
cLogP
1.46
TPSA
144.23
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PDE5
Phosphodiesterase (PDE)
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data