General
Preferred name
ETHCHLORVYNOL
Synonyms
Normoson ()
Nostel ()
Etclorvinol ()
Alvinol ()
Ethchlorvynol civ ()
Roeridorm ()
Serenesil ()
NSC-30372 ()
Serensil ()
Arvynol ()
Placidyl ()
P&D ID
PD046235
CAS
95853-67-1
113-18-8
Tags
available
drug
Drug indication
Insomnia
Drug Status
approved
withdrawn
illicit
Max Phase
4.0
First approval
1961
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Ethchlorvynol is a sedative drug and schedule IV (USA) controlled substance. It produces cerebral depression, however the exact mechanism of action is not known.
MOA
Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
INDICATION
Used for short-term hypnotic therapy in the management of insomnia for periods of up to one week in duration; however, this medication generally has been replaced by other sedative-hypnotic agents.
TOXICITY
Symptoms of overdose include thrombocytopenia.
METABOLISM
About 90% of a dose is metabolized in the liver. Some ethchlorvynol may also be metabolized in the kidneys. Ethchlorvynol and metabolites undergo extensive enterohepatic recirculation.
HALF-LIFE
Plasma half-life is approximately 10 to 20 hours, terminal half-life is 21-100 hours.
ABSORPTION
Rapidly absorbed from gastrointestinal tract.
DESCRIPTION
Ethchlorvynol's use has largely been replaced by safer alternative hypnotics.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
144.03
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
1.51
TPSA
20.23
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
0.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Hypnotics and Sedatives
Source data
