General
Preferred name
GR-55562
Synonyms
GR 55562 dihydrochloride ()
GR55562 ()
GR 55562 (hydrochloride) ()
GR 55562 ()
P&D ID
PD046134
CAS
172854-55-6
159533-25-2
159533-26-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GR 55562 hydrochloride is a selective 5-HT1B receptor antagonist. GR 55562 hydrochloride can be used for the research of nerve disease[1].
DESCRIPTION GR 55562 dihydrochloride is a selective and competitive 5-HT1B (5-HT1Dβ) silent antagonist (pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors, respectively). (BOC Sciences Bioactive Compounds)
DESCRIPTION Bradykinin B2 antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
BOC Sciences Bioactive Compounds
gr-55562-dihydrochloride-cas-159533-25-2-item-119188
Concise Guide to Pharmacology 2017/18
113
Concise Guide to Pharmacology 2019/20
113
Concise Guide to Pharmacology 2021/22
113
Concise Guide to Pharmacology 2023/24
113
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM8L1Z2
DrugMatrix
EUbOPEN Chemogenomics Library
EUB0001014
Guide to Pharmacology
113
MedChem Express Bioactive Compound Library
HY-W010869
Tocris Bioactive Compound Library
1054
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
375.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
4.2
TPSA
65.46
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
5-HT1B Receptors
MOA
Antagonist
Target
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
1 uM
Source data