General
Preferred name
CHLORCYCLIZINE HYDROCHLORIDE
Synonyms
(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) ()
Chlorcyclizine hydrochloride (1:x) ()
Chlorcyclizine (hydrochloride) ()
NSC-169496 ()
AH-289 ()
Perazil ()
Di-paralene ()
Chlorcyclizinium chloride ()
Chlorcyclizine monohydrochloride ()
Histantin ()
Chlorcyclizine hcl ()
P&D ID
PD045972
CAS
1620-21-9
14362-31-3
Tags
drug candidate
available
Drug Status
investigational
Max Phase
1.0
Drug indication
chronic hepatitis C virus infection
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM). It is believed to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), targeting viral entry into host cells. Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
The hydrochloride salt form of Chlorcyclizine which could be used as an antihistamine agent and is also found to have anticholinergic effect at some extent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Prestwick Chemical Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
336.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.1
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
Solubility
~10 mg/ml in PBS (pH 7.2).
Source data
