General
Preferred name
DIPIVEFRIN HYDROCHLORIDE
Synonyms
Dipivefrin HCL ()
Dipivefrin (hydrochloride) ()
Dipivefrine (hydrochloride) ()
Dipivefrine, Propine, Pivalephrine ()
Dipivefrine hydrochloride ()
Propine ()
Akpro ()
P&D ID
PD045909
CAS
64019-93-8
Tags
available
prodrug
drug
Drug Status
approved
Max Phase
4.0
First approval
1980
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea[1][2].
DESCRIPTION Dipivefrin hydrochloride (Dipivefrin HCl) that is available as an ophthalmic solution is a prodrug of adrenaline, which is used to treat glaucoma. (TargetMol Bioactive Compound Library)
Compound Sets
7
Cayman Chemical Bioactives
24028
ChEMBL Approved Drugs
CHEMBL1200833
ChEMBL Drugs
CHEMBL1200833
MedChem Express Bioactive Compound Library
HY-B1323
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
dipivefrin-hydrochloride
TargetMol Bioactive Compound Library
T0103
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
387.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
1
cLogP
3.26
TPSA
84.86
Fraction CSP3
0.58
Chiral centers
1.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChR
Adrenergic Receptor
Endogenous Metabolite
Pathway
GPCR/G protein
Neuroscience
Metabolic Enzyme/Protease
Source data