General
Preferred name
NARINGENIN
Synonyms
Salipurpol ()
Naringenine ()
(±)-Naringenin ()
(¡À)-Naringenin ()
(+/-)-Naringenin ()
(??)-Naringenin ()
P&D ID
PD045821
CAS
67604-48-2
93602-28-9
Tags
available
drug candidate
natural product
nuisance
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(¡À)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (¡À)-Naringenin promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-¦ÊB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research[1][2][3].
PRICE
29
DESCRIPTION
(??)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
DESCRIPTION
Naringenin is a citrus fruit flavanone. It acts as an inhibitor of TRPM3 ion channel activity .
(GtoPdb)
DESCRIPTION
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
11
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
272.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
2.51
TPSA
86.99
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
1
Nonspecific/NOS
Flavonoid
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
BKCa-channel
Potassium Channel
Apoptosis
Caspase
NF-κB
Toll-like Receptor (TLR)
Pathway
Immunology/Inflammation
Membrane Transporter/Ion Channel
NF-¦ÊB
Source data
