General
Preferred name
BYK-191023
Synonyms
BYK 191023 dihydrochloride ()
BYK 191023 (dihydrochloride) ()
BYK 191023 (hydrochloride) ()
P&D ID
PD045041
CAS
1216722-25-6
608880-48-4
Tags
available
drug candidate
Drug indication
Inflammation
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS [1].
DESCRIPTION Potent gamma-secretase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 = 86, 17000, 162000 nM for iNOS, nNOS and eNOS, respectively) acting in a NADPH- and time-dependent manner. BYK 191023 decreases the nitrite levels in rats, and reverses pathological hypotension in the rodent endotoxin model. (BOC Sciences Bioactive Compounds)
Compound Sets
5
BOC Sciences Bioactive Compounds
byk-191023-dihydrochloride-cas-1216722-25-6-item-119020
Cayman Chemical Bioactives
13177
DrugMAP
DMAWMDN
MedChem Express Bioactive Compound Library
HY-107584
Tocris Bioactive Compound Library
2866
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
254.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
2.15
TPSA
63.69
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
iNOS
MOA
Inhibitor
Pathway
Immunology/Inflammation
Target
NO Synthase
Source data