General
Preferred name
FLAVOKAWAIN B
Synonyms
Flavokavain B ()
Flavokawin B ()
2'-Hydroxy-4',6'-Dimethoxychalcone ()
Flavokawain B (CRM) ()
P&D ID
PD044718
CAS
1775-97-9
76554-24-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates Bcl-2 with concomitant increase in Bax level. Flavokawain B inhibits NF-¦ÊB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation[1][2][3][4][5][6][7][8][9][10][11][12][13].
PRICE 176
DESCRIPTION 1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-??B and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
DESCRIPTION 1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells. (TargetMol Bioactive Compound Library)
Cell lines
12
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
41058
19652
MedChem Express Bioactive Compound Library
HY-N2132
Selleckchem Bioactive Compound Library
flavokawain-b
TargetMol Bioactive Compound Library
T6S0735
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
284.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.31
TPSA
55.76
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Akt
Bcl-2 Family
Caspase
MMP
NF-κB
p38 MAPK
PARP
PI3K
Reactive Oxygen Species (ROS)
Reactive Oxygen Species
Pathway
NF-¦ÊB
Cell Cycle/DNA Damage
Epigenetics
Immunology/Inflammation
MAPK/ERK Pathway
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Source data