General
Preferred name
Lactisole
Synonyms
na-PMP ()
Lactisole (free acid) ()
LACTISOLE SODIUM ()
NSC-352144 ()
LACTISOL ()
P&D ID
PD044686
CAS
4276-75-9
150767-88-7
150436-68-3
13794-15-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
nutritional disorder
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].
PRICE 29
DESCRIPTION Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets[1][2].
DESCRIPTION Lactisole is a sweet taste receptor antagonist that suppresses perception of sweetness in humans. It blocks a heterodimeric receptor comprised of T1R2+T1R3, which detects sweet-tasting compounds. (BOC Sciences Bioactive Compounds)
DESCRIPTION Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor (TargetMol Bioactive Compound Library)
Compound Sets
7
BOC Sciences Bioactive Compounds
2-p-methoxyphenoxy-propionic-acid-cas-150436-68-3-item-199888
Cayman Chemical Bioactives
18657
ChEMBL Drugs
CHEMBL3715108
CHEMBL573448
Guide to Pharmacology
13900
MedChem Express Bioactive Compound Library
HY-W030796A
HY-W030796
ReFrame library
TargetMol Bioactive Compound Library
T35795
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
196.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
1.55
TPSA
55.76
Fraction CSP3
0.3
Chiral centers
1.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Sweet taste receptor
Taste receptor
Pathway
GPCR/G protein
Metabolism
Source data