General
Preferred name
BAY 61-3606 (hydrochloride)
Synonyms
BAY 61-3606 hydrochloride ()
P&D ID
PD043804
CAS
1615197-10-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
DESCRIPTION BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM; IC50 = 10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. It shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. (BOC Sciences Bioactive Compounds)
Compound Sets
3
BOC Sciences Bioactive Compounds
bay-61-3606-hydrochloride-cas-1615197-10-8-291408
Cayman Chemical Bioactives
11423
MedChem Express Bioactive Compound Library
HY-76474A
External IDs
8
Properties
(calculated by RDKit )
Molecular Weight
426.12
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
3.07
TPSA
116.66
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
SYK
Pathway
Protein Tyrosine Kinase/RTK
Solubility
Soluble in DMSO.
Source data