General
Preferred name
trans-2-hydroxycinnamic acid
Synonyms
2-Hydroxycinnamic acid ()
O-COUMARIC ACID ()
P&D ID
PD042969
CAS
583-17-5
614-60-8
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity[1][2][3][4].
PRICE 29
DESCRIPTION 2-Hydroxycinnamic acid is a natural product isolated from Angraecum fragrans, has photooxidant activity. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
3
Compound Sets
5
DrugBank
DB01650
DrugMAP
DM86HTZ
MedChem Express Bioactive Compound Library
HY-W012531
Selleckchem Bioactive Compound Library
2-hydroxycinnamic-acid
TargetMol Bioactive Compound Library
T7991
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
164.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.49
TPSA
57.53
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HIV
SARS-CoV
Bacterial
Endogenous Metabolite
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Source data